Portsmouth defender Younes Kaboul returns from a one-match ban.
But there are doubts over the fitness of goalkeeper David James, who sat out his side's 2-1 loss at Chelsea on Wednesday night with the calf problem which has troubled him for much of the season.
Asmir Begovic stands by to replace him, but striker Frederic Piquionne should be fit despite limping out at Stamford Bridge with cramp.
Liverpool defender Glen Johnson has been passed fit to face his former club Portsmouth at Fratton Park on Saturday.
The England right-back, who left Pompey to move to Anfield in the summer, has been troubled by a hamstring injury and missed Wednesday's victory over Wigan as a precaution.
Striker Fernando Torres is likely to start having come off the bench to score against the Latics but winger Albert Riera still has a hamstring problem and is not fit.
Forward Ryan Babel returns to the squad after an ankle injury.
Portsmouth: James, Begovic, Mokoena, Kaboul, Mullins, Kanu, Vanden Borre, Piquionne, Ben-Haim, Yebda, Dindane, Brown, Wilson, Hreidarsson, O'Hara, Smith, Boateng, Diop, Finnan.
Liverpool: Reina, Johnson, Carragher, Agger, Insua, Benayoun, Gerrard, Mascherano, Aquilani, Kuyt, Torres, Cavalieri, Lucas, Aurelio, Skrtel, Kyrgiakos, Ngog, Babel, Degen.
