Mexico go into the match lying in fourth place in the six-nation final group, from which three teams advance directly to the World Cup finals in South Africa. The fourth-placed team must play off against a team from South America for a berth.
Costa Rica lead North American regional qualifying with 12 points to 10 for the US squad. Honduras are third with Mexico in fourth.
Mexico received a massive morale boost heading into the match with a 5-0 victory over the United States in the Gold Cup final on July 26.
But that was against a young US side that didn't include stars such as
On Wednesday US coach Bob Bradley will field a full-strength team as the Americans vie for a first-ever victory over Mexico at Azteca. They have only managed one draw there - a goalless draw in a 1997 World Cup qualifier.
